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Loosehead prop Rhys Gill of Saracens, who are also through to the last eight of the Heineken Cup, comes into the side for Jenkins after winning his other cap two years ago - appearing from the bench against Ireland at Croke Park in the 2010 6 Nations.
Blues wing Cuthbert, who made his debut against Australia before Christmas, makes his first start profiting from the retirement of Shane Williams, with Scarlets wing George North (who played in all 7 RWC matches last year) switching flanks to take the No11 jersey synonymous with Wales' top try scorer.
Cardiff Blues take on Heineken Cup holders, Leinster Rugby, in the quarter-final at the Aviva Stadium on Saturday, 7 April (kick-off: 17.45).
