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"Harlequins have a very young team and they can be dangerous at any time," said Whitford.
"They are leading the premiership with an offensive and dynamic brand of rugby and are playing full of confidence.
"It's going to be a big game and a huge challenge.
"We know we must have a good base and set piece and have to be strong in defence and if we can handle that we will be able to play our game.
"Our aim was to get a home quarter-final and we have got that and it's a great reward for our supporters and it's really good for the city as a whole.
"We know we could be inline for a home semi-final but we have to take games one at a time so we are not looking past Harlequins."
