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Birkett, who made his Wasps debut back in 1999, will join a prestigious group of Wasps players to reach the milestone which include Lawrence Dallaglio, Alex King, Josh Lewsey, Simon Shaw and Joe Worsley when he runs out at Adams Park on Sunday afternoon.
The 6ft 6ins and 17st 4lbs second row doesn't hide his pride at still being at a club which obviously means a lot to him for so long and passing a landmark shared by so many greats of the English game.
"I definitely didn't think I would last this long!, " said Birkett.
"It's been bruising but a lot of fun and I am very proud of the fact that I am still playing and had such a lot of fun along the way. It has been a fantastic experience doing it all with Wasps and I am very lucky.
Birkett's first game was against London Irish at Loftus Road where he came off the bench in the then Allied Dunbar Premiership joining likes of Shaw, King, Paul Volley and Will Green on the field.
Birkett was part of the London Wasps side which dominated the English and European gameand won the Heineken Cup, Premiership titles and numerous other domestic trophies. But for him one game will always live long in the memory.
"Our game in Lansdowne Road against Munster in the Heineken Cup Semi-Final in 2004 without a doubt has been the one I will never forget," said Birkett.
"We won 32-37 and it was just incredible from start to finish. Everything about it was fantastic. The game itself was immense and the lead changed hands a few times, the atmosphere was also unforgettable.
"I had never experienced anything like it. There were thousands of home fans baying for our blood and then after the game they were all patting us on the back and saying fair play you guys were awesome.
"I have a lot of respect for fans like that who really appreciate rugby and they are not just blinkered."
Birkett admits he is a rare example of a one-club man in the professional era and that the idea of players making 250 appearances for one Club will become the exception, not the rule.
"It is a sad thing but it's inevitable," said Birkett. "As the game becomes more financially viable players are going to start looking at their career and the fact that it's a job and you have to look after your career and your family.
"Everyone would love to stay at the Club they started at because you get a real fondness for where you come from and I consider myself hugely lucky to have been able to do it. The last few years at Wasps have been tough but I haven't stopped enjoying the game and the young guys we have here now really do keep your spirit ticking along."
Prop Tim Payne, the England international, will also pass a personal milestone against Bordeaux Begles when he makes his 50th European appearance for the Club.
