Exeter Chiefs will be expected to add to I Cavalieri Prato's woes when they bid to keep their hopes of a last eight place alive when the two sides clash on Italian soil on Saturday.
The English Premiership outfit, who are level on points after three wins in the Pool with French side Perpignan, will be determined to get a bonus point victory at the Stadio Lungobisenzio.
The Chiefs know they have to put themselves in pole position before they host Perpignan in what looks like a thrilling finale to the Pool to decide who qualifies for the knockout stages.
The Italian part-timers, who are in only their second season of European rugby, have lost all four games in their Pool and are still looking for their first victory in this season's tournament.
Perpignan v Newport Gwent Dragons
(Saturday January 14, KO:20.55)
Perpignan will be looking for revenge and a Amlin Challenge Cup quarter-finals place when they host the Newport Gwent Dragons at the Stade Aime Giral on Saturday evening.
The Catalans are joint Pool 4 leaders with the Exeter Chiefs and are four points ahead of the Welsh side and will be looking for a victory to ensure their place in the knockout stages.
The Dragons will be looking to achieve their own 'double' over the Top 14 side in the French side's backyard after their win at Rodney Parade and will want to get their own campaign back on track after their last defeat to the Chiefs.
The Men of Gwent have a slim chance of qualification and know they need to return from France with a victory to stand any chance of a quarter-finals place.