The Ospreys will be looking to keep their unbeaten record against Italian sides when they host Benetton Treviso, who they drew with the last times the sides met earlier in Pool 5, at the Liberty Stadium.
The Welsh side's hopes of a quarter-final place are slim, with Saracens and Biarritz Olympique in pole position to fight it out for a place in the knockout stages, but they can still have a major impact on who does qualify.
The Ospreys will be determine to keep their 100 percent record against Italian opposition and to re-establish their winning record at 'Fortress Liberty' in the Heineken Cup after their home 13-16 defeat to Saracens last time out.
The Liberty Stadium outfit failed to qualify for the knockout stages of the tournament for the first time in three years last season and face ignominy of doing the same this season.
Treviso, who have never made it out of the Pool stages in the tournament, will be looking to go one better and will be looking for their first win against their fellow Pro 12 outfit after their draw on Italian soil.