Stade Francais Paris, last season's beaten finalists, will be looking to extend their three-matching winning streak when Italian outfit, Banca Monte Crociati, travel to Paris.
The French side are top of the table in Pool 1, having beaten the Italians, Worcester Warriors and the Bucharest Wolves, and will be determined to repeat last weekend's 57-0 victory in Italy.
Banca Monte Crociati, who are in only their second season of European rugby, are still looking for their first win in this season's tournament.
Worcester Warriors v Bucharest Wolves
(Saturday December 17)
Worcester Warriors took maximum points in Romania when these two sides met last weekend, but were made to work hard for the victory by an impressive Bucharest outfit.
The Wolves held the lead going into the final quarter of that game before two late Worcester tries and Richard Hill will be looking for a much improved performance from his side in the second of the back-to-back games.
The victory kept Worcester in second place in Pool 2 and they will need to take three victories from their final three outings to be in with a chance of reaching the knock-out stages.