Newcastle Falcons will be looking to keep their unbeaten record when they travel to Italy to face Petrarca on Saturday.
Alain Tait's Falcons recorded a 27-19 victory over French side Lyon at Kingston Park last weekend and will be looking to do the same on the road in Italy.
Petrarca, who are in the 11th season of Amlin Challenge Cup rugby, will want to get their first victory of the Pool after the one-sided 53-22 defeat to Toulon in France last weekend.
Lyon v Toulon
(Saturday November 19 KO 20:45)
The battle of French and European rugby's new boys, Lyon and Toulon, in France will be one of the truly intriguing contests of the second round of the Amlin Challenge Cup.
Both clubs have really emerged in France and been the talk of the Top 14 and have made no secret of their ambitions to scaled the heights of European rugby over the next few years.
Lyon have followed in the footsteps of Toulon and been promoted to French rugby's top flight and their clash at the Stade Felix-Mayol promises to give a real insight into two prospective superpowers of the European game.
Toulon are top of Pool 2 after their comprehensive 53-22 bonus point victory over Italians Petrarca in Round 1, while Lyon will be hoping to kick-start their campaign after a disappointing 27-19 defeat away to Newcastle Falcons.