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Additionally French lock Romain Millo-Chluski looks set to miss the next two rounds of Europe's premier competition and possibly the start of the Six Nations championship after picking up a similar injury to Kelleher.
Guy Noves' are currently unbeaten at the helm of Pool 6 and will be boosted by the return to fitness of French duo David Skrela and William Servat.
The fly-half and hooker are in line for a return to the side after missing Toulouse's Top 14 defeat by Stade Francais last weekend.
Toulouse kick off against the Dragons at 14:30 at the Stade Ernest Wallon on Saturday and then travel to England to face former European Champions London Wasps the following weekend.
