Harlequins host newcomers I Cavialleri Estra to the Twickenham Stoop in this weekend's second round of the Amlin Challenge Cup.
I Cavialleri Estra should not be underestimated after narrowly beating last season's semi-finalists Connacht 23-21 last Saturday.
Director of Rugby at Harlequins, Conor O'Shea said: "They got a brilliant result last week on their maiden game in Europe against Connacht but now we are all forewarned and the adage that there are no easy games anymore rings very true."
Harlequins will look to bounce back from their 16-12 defeat at the Stade Jean Dauger at the hands of French side Bayonne.
Connacht face Bayonne at the Sports Ground this weekend and t hey are aiming to put the defeat to minnows I Cavialleri Estra behind them and hope to kick-start their European campaign with a win.
Bayonne will hope to keep their confidence high after their opening day result.