Harlequins, the reigning English Premiership champions, need only a solitary point from their final two Pool 3 games to qualify for the lucrative knock-out stages.
The English aristocrats have been the dominant team in this Pool and already have a 10-point lead over their nearest rivals in the Pool - Biarritz Olympique - who were finalists in 2006 and 2010.
'Quins will be relishing the prospect of taking on a Connacht Rugby side who caused the Londoners some real heartache in the Pool stages last season when they beat them 9-8 in Galway
This time the English side, who recorded a 30-22 victory in front of a crowd of 8,199 at the Sportsground in the first game between the two sides in October, will be looking to do their own double over the Irish province.
Harlequins are one of three teams, along with French sides Toulon and ASM Clermont Auvergne, who are still unbeaten in this season's Pool stages and have won all four of their games so far.
Match Facts
- Connacht have proved tough opposition for Harlequins in this tournament, winning one clash and narrowly missing out on bonus points with eight-point defeats in the other two.
- Quins are the top points and try-scorers in the Heineken Cup this season, averaging 45 points and over five tries per match.
- Danny Care, the England scrum-half, is the joint-top try-scorer in this season's competition having dotted down four times already.
- Harlequins are aiming for the fifth consecutive victory in the Heineken Cup, their current run of four is their best winning sequence to date. Dan Parks is two points away from hitting 50 points for Connacht in the tournament this season.