Speed merchant Christian Wade, being tipped for international honours, led London Wasps on a try spree at Stadio Maurizio Quaggia as they raced to a 59-12 victory over Rugby Mogliano.
The nine tries earned them the maximum points to go top of Pool 3 just a single point ahead of French big-spenders and star-studded Bayonne.
And the one qualifying place for the knock-out stages is set to go on the line in the back-to-back encounters in Rounds 3 and 4.
Wasps travel to France for the first clash on December 8 and then host Bayonne the following weekend.
Hooker Thomas Rhys Thomas got their first and Joe Launchbury wrapped it up in injury time with the ninth with Thomas Bell adding seven conversions
Wade crossed in the 30th and 63rd minutes with the other seven being shared around as Wasps had no trouble in making it two from two and 10 points in the bank.