Perpignan will be aiming to maintain their winning start to the Amlin Challenge Cup when they host Bizkaia Gernika RT in Pool 2.
The Catalan giants claimed an emphatic 79-12 victory over Femi CZ VEA Rovigo last weekend, running in 10 tries to record their biggest win in European club competition.
And they will be targeting another record-breaking, maximum points haul against Spanish new-boys Gernika, who crashed to a 85-5 defeat against Worcester Warriors.
Both Perpignan and Worcester will be aiming to put as many points on the board as possible before their crucial December double-header.
Perpignan have never won a piece of European silverware but are regular competitors in the knock-out stages of both the Heineken and Amlin Challenge Cups.
Veteran prop, and captain, Nicolas Mas is set to return to action in the clash against the Basque club while Richard Haughton and Henry Tuilagi are expected to shake off injuries picked up against Rovigo.
Gernika will be desperate to restore some pride following the harsh lesson handed out by Worcester but are set for another tough day at the Stade Aimé Giral.