A bonus point win in France handed London Irish the perfect start to their campaign but they will be wary of a Mont de Marsan side who proved more than a handful for Gloucester Rugby.
Despite struggling for form in the Premiership, the Exiles found their rhythm at Bordeaux-Begles where they hit their hosts for six tries.
Samoan international Sailosi Tagicakibau led the rout with a brace while Chris Hala'ufia, Topsy Ojo, Jonathan Joseph and Halani Aulika also crossed in the 43-16 win, their fourth in their last five visits to France.
New Fijian prop Jeremaia Yanuyanutawa is set to get his first taste of European rugby following his arrival at the Madejski Stadium from ACT Brumbies last month.
Mont-de-Marsan are still waiting for their first win of the season and already face an uphill task after failing to get the better of 14-man Gloucester at Stade Guy Boniface.
However two penalties from the boot of Jean-Baptiste Claverie at least secured a losing bonus point that offers a glimmer of hope.