New Italian outfit Zebre make their debut in the Heineken Cup looking to register their first win since they were formed following the collapse of Aironi in the summer.
Zebre face Connacht Rugby at Stadio XXV Aprile and in a Pool that includes Biarritz Olympique and English champions Harlequins, this tie could represent their best chance of success.
Captain and international lock Marc Bortolami will lead the Italians who will also look to the creativity of former Waratahs utility back Daniel Halangahu.
Connacht kick-off their only second season in the top tier of European rugby following 15 years in the Amlin Challenge Cup.
New signing Dan Parks, 14th in the all-time scoring chart in Europe, will prove influential as he aims to add to his 355 points.
Eric Elwood's men have already won in Parma this season, 30-17 in the Pro12, and aim to improve on their solitary win in the Heineken Cup.