Bizkaia Gernika RT will take their Amlin Challenge Cup bow against Worcester Warriors on Saturday.
The Spanish champions have never competed in European competition but remain unbeaten in the national league - with five wins from five.
There is sure to be a festival of colour in the Basque town, which was written into history during the Spanish Civil War and encapsulated in Picasso's famous painting.
Worcester have not enjoyed such a bright start to the season, with just one win from six matches in the English Premiership, but will be over whelming favourites.
They were runners-up in the competition in 2008, losing to Bath in the final, and boast a wealth of international and European experience.
Former England international Andy Goode has twice won the Heineken Cup with Leicester Tigers, while both Neil Best and Ceri Jones have previously clinched the Amlin Challenge Cup.