Grenoble kicked off their Amlin Challenge Cup campaign in style as they hammered I Cavalieri Prato in Pool 5.
The French side marked their return to Amlin Challenge Cup competition after a seven-year absence with a comprehensive 59-3 success at Stade Lesdiguieres.
Grenoble crossed for eight tries courtesy of eight different scorers to build on their fine start in the Top 14, although it took them a while to get going on Friday night.
The home side had touched down just once in the first 25 minutes and twice in the opening 33 but the game to bed in a 15-minute spell either side of the interval.
A penalty try on 34 minutes added to earlier efforts from Matthieu Nicolas and Clement Darbo, before quick-fire scores from Rudolf Coetzee and Anthony Hegarty helped Grenoble build on a 19-3 half-time lead.
I Cavalieri Prato did at least keep their line intact for a 10-minute spell before the hour mark but further tries from Flavein Nouhaillaguet, Gregory Fabro, Alexandre Pollard and Jonathan Pelissie completed the rout.
Grenoble will now be looking for more of the same when they face a much sterner challenge at Stade Francais Paris in Round 2, while I Cavalieri Prato turn their attentions to a home time with tournament debutants London Welsh a week on Saturday.