Perpignan will look to put their Top 14 woes behind them by getting their Amlin Challenge Cup campaign off to a successful start in Italy.
The French side slumped to a shock 28-23 defeat at Grenoble last weekend and currently lie ninth in their domestic table.
Perpignan failed to qualify for last season's quarter-finals after away defeats to Newport Gwent Dragons and Exeter Chiefs, but did secure a victory on Italian soil last season.
And director of rugby Marc Delpoux, with Wales international James Hook pulling the strings at fly-half and new signing Luke Narraway settling in following his move from Gloucester, will hope there is a repeat of the 30-13 win over I Cavalieri Prato.
Meanwhile, Rovigo have won just six times from 56 matches in the Challenge Cup.
But the Italians have not tasted success since beating fellow French outfit Dax 24-11 at the Stadio Mario Battaglini on October, 18, 2008.