Grenoble return to the Amlin Challenge Cup after a seven-year absence and could well prove to be one of the surprise title contenders this season.
The club from the Alps have scaled new heights in the Top 14 this season and lie fifth thanks to their impressive form at Stade Lesdiguieres.
They have already seen off the visits of Perpignan, Racing-Metro and Stade Francais, who they will meet again in Pool 5, to their home ground.
They start against I Cavalieri Prato and have the vast European experience of Shaun Sowerby, a Heineken Cup winner with Toulouse, at No 8 with former Perpignan play-maker Nicolas Laharrague, with nine years of European rugby under his belt, to pull the strings.
It all adds up to a daunting task for Alberto Chiesa's men from Tuscany who have lost their last 11 games since winning their first fixture in Europe - against Connacht in 2010.
