Twickenham will become the fourth national stadium to stage Heineken Cup Pool stage action this season when London Wasps and Leinster clash in a Round 5 match that could have a major bearing on Heineken Cup quarter-final qualification.
Leinster are three points clear of the former double Heineken Cup champions in Pool 2 and Wasps will need the points from their Twickenham showdown on 17 January, 2009, to stay in the hunt.
Murrayfield - venue for the 2009 and 14th Heineken Cup final on Saturday, 23 May - the Millennium Stadium and Stade de France have all seen Pool matches already this season with over 600,000 fans having gone through the turnstiles for the 48 matches played in the opening four rounds.
And three teams, treble champions Toulouse, Harlequins and Cardiff Blues have made it four from four to head their groups with two matches to come.
The big one in Pool 6 is the Blues' trip to Kingsholm to face Gloucester Rugby the Welsh region four points ahead with each team having also banked two try bonus points.
But Harlequins have the biggest lead of any Pool leader, a commanding six points over Stade Français Paris after Nick Evans clinched back-to-back victories over the French giants in one of the most pulsating finishes in the rich history of the Heineken Cup.
His drop goal, only confirmed after consultation with the video referee, came after three minutes and 59 seconds of second half injury time and an amazing 29 phases.
Toulouse - who will play their 100th Heineken Cup match when they travel to Bath Rugby in Round 6 - are two points clear of 1998 champions Bath with that clash at The Recreation Ground possibly the key to the ultimate group honours.
Meanwhile advance sales for the Edinburgh 09 final have gone through the 32,800 mark and 15,000 of the remaining tickets will be retained for the finalists to share.