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The Saracens player has been drafted into the French squad for the Autumn series in place of the injured Toulouse player Clement Poitrenaud.
An achilles injury forced Castaignede to spend almost a year on the sidelines. He is now back to full fitness and in line to face South Africa, New Zealand and Canada.
Potrenaud picked up his rib injury in Toulouse's victory over Perpignan on Saturday and is expected to be out of action for a month.
French coach Bernard Laporte also has an injury worry over centre Tony Marsh. He injured his groin in Montferrand's 37-10 defeat by Bourgoin at the weekend. Toulouse centre Xavier Garbajosa is standing by to rpelace him.
