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Castres won the first leg 54-25, and will start as strong favourites.
But they will have to make do without their French international hooker Rapheal Ibanez, who is unavailable with a back injury.
Philippe Carbonneau, a two-times winner of the Heineken Cup - with Toulouse in 1996, and Brive in 1997 will captain the Pau side.
Star players centre Damien Traille and No.8 Imanol Harinordoquy are both included as Pau attempt to claw back the 29 deficit from the first leg.
Pau; J-B Peyras-Loustalet; Thierry, J-C Cistacq, D Traille, S Jonnet; D Aucagne, P Carbonneau (capt); F Guatieri, M Tincu, O Sourgens, G Morgan, M Jolly, M Barrague, P Som, I Harinordoquy
Replacements; M Larrouy, D Laperne, G Bortolaso, J Carre, N Duffard, M Pearson, N Sestaret
Castres Olympique; L Marticorena; U Mola, N Raffault, S Roque, L Arbo; R Teulet, A Albouy; M Reggiardo, R Vigneaux, J Garcia, D Barrier (capt), N Spanghero, R Froment, G Taussac
Replacements; D Narjissi, S Sparks, B Moyle, P Furet, Bisaro, C Stoica, N Nadau
