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Irish international duo Shane Horgan and captain Reggie Corrigan seem destined to watch the game from the sidelines.
Corrigan suffered a broken wrist in the RBS 6 Nations win over Italy on February 22.has, and has not taken part in any full-contact training sessions.
Horgan has not played since suffering a thigh injury the previous weekend in the first half against Scotland at Murrayfield.
A Leinster spokesman said: "Reggie Corrigan is rated as highly unlikely for Saturday's match while Shane is an unlikely.
"They are having a day off today but will resume training tomorrow afternoon and we'll check on them after that.
"No decision will be taken until Friday morning but Reggie has done no contact work.
"Shane has a quadriceps strain and he's done some light running but nothing more than that."
The match has attracted the biggest ever crowd for a Provincial match in Ireland, with Lansdowne Road a virtual sell-out.
