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Edinburgh are currently leading the way with four wins and a draw from five starts and will be looking to build on the lead in the eight match tournament when they travel to Glasgow.
The Glasgow side are still looking for their first win and will go into Friday night's game at Hughenden with a caretaker coach at the helm after the club parted company with head coach Kiwi Searancke.
Richie Dixon, currently the Scottish Rugby Union's head of coach development, will return to his old job on a caretaker basis to steer Glasgow through their final four games.
Searancke decided to leave Scotland to pursue his career elsewhere and Glasgow chief executive David Jordan is currently reviewing the coaching structure for next season.
Glasgow's assistant coach Steve Anderson has been seconded to elite performance analysis for the SRU under the direction of national coach Ian McGeehan, while the second assistant coach, Gordon Macpherson remains at the club.
"We have a very important sequence of games throughout April in the Bank of Scotland Pro Rugby Cup and to guide the players through that period, Richie Dixon, the SRU's head of coach development, will return to Glasgow on a caretaker basis to lead the coaching of the team," explained Jordan.
The top two teams in the competition will qualify automatically for the Heineken Cup next season. Edinburgh and Glasgow took the places in this season's competition.
Current Standings in Bank of Scotland Pro Rugby Cup
P W L D F A Diff Pts
Edinburgh 5 4 0 1 176 68 108 21
Borders 4 2 2 0 99 125 -26 9
Glasgow 5 0 4 1 57 139 -82 2
