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The meeting in front of a full house of 36,500 at Stadium de Toulouse on Saturday will have a certain air of déjà vu about it as it will be the fifth head-to-head between the sides in less than 18 months, Edinburgh Rugby beating the double Heineken Cup winners for the first time when they stunned the champions with a 23-16 victory back in December.
And Scotland captain and Edinburgh star Chris Paterson is adamant they will not be going to make up the numbers.
"The standard of this competition is so high that it's very difficult for anyone to qualify for the quarter-finals," said Paterson.
"In that respect we are proud to be the first Scottish team to qualify for the last eight but, at the same time, we are not going to be content with simply participating in the quarter-finals.
"Our aim will be to get through to the semis. People are entitled to have their opinions - and we know we are seen as massive underdogs - but this is knock-out rugby and it's what happens on the day that counts.
"We won all our away matches, except the last one against Toulouse, but the only experience we will draw on for this match will be the fact that we have played here twice in the last two seasons.
"We wouldn't do ourselves, our families or our supporters any service if we had any other thought in our heads other than that we can win this match. That is what we are going there for.
"Edinburgh as a unit is quite new to professionalism but there are individuals in the team to whom the top stage is nothing new at all. We have a former All Black captain in Todd Blackadder and players with 40 or 50 caps - collectively a core group of players who are totally excited by this challenge. And then there are the young players who are not at all overawed, they just want to go out and play.
'Toulouse are truly a world class team with so much individual brilliance. It's a huge and exciting challenge to be playing them at Le Stadium in front of so many people. As a professional player, you want to be playing at these big grounds with a big atmosphere.
"The Six Nations is obviously still fresh in everyone's mind but in two weeks it will be history and Toulouse and Edinburgh play a different game to that of France and Scotland so it would be stupid to compare the two.
"The Six Nations is over and there has been no mention of Scotland within the Edinburgh squad since then. There is a great team spirit and work ethic at Edinburgh and we are looking forward to playing together again.
"It's a great achievement to be in the last eight but we're not getting carried away and we will work hard to be good enough on the day to meet the challenge.
"It's a reward for everyone and it's also a testament to the hard work of former players that paved the way for us - like Bryan Redpath and Craig Chalmers."
Toulouse: TBC
Edinburgh: Backs Mike Blair, Graeme Burns, Alistair Dickson, Marcus Di Rollo, Craig Joiner, Brendan Laney, Derrick Lee, Chris Paterson, Tom Philip, Hugo Southwell, Alistair Warnock, Simon Webster,
Forwards Todd Blackadder, Joel Brannigan, Simon Cross, Carlo Di Ciacca, Andrew Dall, Dougie Hall, Nathan Hines, Allister Hogg,
Allan Jacobsen, Alastair Kellock, Andrew Kelly, Scott Murray, Craig Smith, Alasdair Strokosch
