Coach Michael Cheika says that his team is energised at the prospect of playing the English champions and two-time Heineken Cup winners in one of the most imposing arena's in World rugby.
The tie of Round 5 takes place on Saturday afternoon at Twickenham with the winners of the Magners Leeague tackling the Guinness Premiership champions for the second time this season.
The first leg went the way of the Irish, with a comprehensive six-try, 41-11 victory in Dublin, and coach Cheika siad: "Now that the game is here, you can feel the energy. Bernard (Jackman) participated in training on Monday and we're confident that he will be available for selection. CJ (van der Linde) didn't train yesterday but we'll wait and see.
"We have had a plan, since the week off before the Ulster game, on how we wanted to bring players back into the team and we feel that we're pretty well on track for that.
"The players who are not in the starting XV still have a major role to play in terms of making an impact and finishing games off. The form of some players has put pressure on others, and I'm still hopeful that (Shane) Jennings will have an opportunity to play because we'll be appealing that decision tomorrow.
"We understand the strengths of all our players in the squad. Tailoring to our game-plan, we will then select the team. We're going to try to use our different talents to impact changes and that's something that we're very mindful of.
"I've got a lot of belief in the team. I always have done. I'm not naïve and I know that we have needed to play better (recently), but we're aware that we're playing against very different forces.
"We have gained a lot more self belief and you could see that in the body language at the end of the Cardiff game. A lot of our guys have had some good moments in Twickenham at international level for Ireland, but this weekend it's all about the final product that we produce on the day."