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London Irish beat Harlequins 20-19, Topsy Ojo getting the Exiles' only try.
Wasps' 21-19 victory over Saracens saw the Londoners outscoring Sarries by two tries to one.
Bristol produced the result of the weekend, chalking up five tries to beat Worcester Warriors 41-11.
Olly Morgan and Jack Adams were on target as European Challenge Cup champions Gloucester beat Bath 24-19, Danny Grewcock grabbing a brace for the visitors.
Meanwhile in the Magner Celtic League last year's champions Ulster got off to the perfect start with a home victory over Llanelli Scarlets, running in three tries in a 31-16 triumph.
Connacht lie second after an impressive opening day result, beating Border Reivers 29-15 at Netherdale.
Cardiff Blues scored the result of the weekend to go third, beating Heineken Cup champions Munster 22-13.
At the Liberty Stadium, the boot of James Hook was the difference as the Ospreys beat Edinburgh Gunners 17-11.
Newport Gwent Dragons edged a thriller against Glasgow Warriors, kicking a last minute penalty to win 24-23.
Leinster had a free weekend.
