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Changes in the pack include the reinstatement of international hooker Steve Thompson and prop Tom Smith to the starting front row, and Darren Fox has also come into the back-row to replace Mark Soden. South African lock Selborne Boome has made a return from a back injury to feature on the bench.
Commenting on Saturday's narrow league win over NEC Harlequins, head coach Budge Pountney said: "I would have liked us to have played a bit better against Harlequins but a win is a win. We will go to France in a relaxed state of mind. We will not have to worry about league position this weekend and just go full on into it.
"It is a massive game in which we are most definitely the underdogs and everybody thinks we are just turning up to make up the numbers. We have lost to Toulouse in a quarter-final before, so we know about the fantastic atmosphere their fans create and the team is really looking forward to it."
