Ben Hinshelwood will lead Worcester out at Sixways on Saturday for the First Leg of their European Shield semi-final clash with Leeds Tykes looking to go ahead in the season's head-to-heads between the Zurich Premiership rivals.
Results so far have gone with home advantage - the Leeds winning 24-19 at Headingley in October and Worcester 22-15 at Sixways in February - and Worcester accept that a win in the first leg on their own patch is the key.
"We have had two very close - and two very hard - games against Leeds and it is fair to say we each know all about one another," said John Brain, Director of Rugby.
"They have a lot of quality players and they will be on a high after beating Premiership leaders Leicester at the weekend while we were very disappointed to lose by a point to Saracens.
"We just have to accept that 19-18 defeat and get down to the business of facing Leeds and we must have the aim of taking a reasonably healthy advantage into the Second Leg at Headingley on Friday, 22 April.
"And if we can produce a similar performance to the one we managed against Saracens then I believe we will be okay. We are all looking forward to the two matches against Leeds."
Worcester are sweating over the fitness of prop Chris Horsman, lock Tim Collier and back row forward Pat Sanderson but are adamant they intend to go all the way in the tournament.
"If we can do that it means we will have an interest and have games right through to the end of the season and that has to be good for the club," added Brain.
With the semi-finals coming down to all-English and all-French affairs, the final on the weekend of 20 - 22 May is guaranteed to be an Anglo-French showdown as to who takes over the title from Montpellier.