Warriors coach Brain watched his siderecordto a 19-14 victory against Italian side Catania, to put his side in a strong position after two rounds in the European Challenge Cup
Warriors prop Tievita Taumoepeau powered his way over for the game's first try, and was joined on the scoreboard by team-mates Kai Horstmann and Mark Tucker. Catania winger Benjamin De Jager scored a try in each half, but Worcester held on for a crucial victory.
In Pool 4, Brive thumped Italian club L'Aquila 64-22, with backrower Alexandre Maleyrie scoring twice.
The French side ran in 10 tries at Parc Municipal de Brive, with former France winger Ludovic Valbon also bagging a brace.
Veteran Test prop Christian Califano scored a crucial try as Agen turned a 6-all halftime deadlock into a 23-6 win over Pau in Pool 2.
Fullback Arnaud Mathet added another try as Pau were confined to two penalty goals from Argentinian outside-half Gonzalo Quesada.
Bayonne scored four tries to beat Toulon 28-19 in Pool 3. The visitors scored three converted tries to open up a 21-0 lead at halftime, with outside-half Henri Vermis' second-half five-pointer holding off a Toulon comeback.