Biarritz Olympique centre Damien Traille will miss several games for his side after after breaking his arm against Saracens.
Traille was forced off before half-time in Biarritz's Heineken Cup defeat at Vicarage Road on Sunday, and will miss next week's pool game against Ulster.
It is likely he will not be available for the third and fourth round matches against Benetton Treviso
He will also miss France's November Tests against Australia, Canada, Tonga and South Africa.
France are already without flanker Serge Betsen, lock Pascal Pape and suspended number eight Julien Bonnaire.