Perpignan prop Perry Freshwater is likely to make his return after his four week ban for this weekend's crucial game against Newport Gwent Dragons at Rodney Parade.
He will be joined by Adrien Planté, AdrienVaki and AdrienTonita who are all returning to the USAP side after spells on the sidelines from injury.
The only loss to the side this week will be prop Sébastien Chobet, out with a rib injury picked up against Benetton Treviso last weekend.
Perpignan trail Pool leaders London Irish by a point so know that to secure their passage into the final eight, a win against the Welsh region is required.
In Round 1, the French side only managed a 23-19 win at their home ground, Stade Aime Giral.
Dragons boss Paul Turner will tell his troops a win is within their grasp and that they need to redeem themselves after being 'taught a lesson' by London Irish last weekend.