Wade has been struggling with a hamstring problem he picked up in training with England earlier this month, while Varndell hasn't played since rupturing his bicep in a training session just a week into the new season. But both men are set to hand Wasps a huge boost in the coming days and weeks, with Wade expected to be fit again this week and Varndell to follow suit shortly after.
"Christian Wade should be available for next week and Tom is another two weeks away," said director of rugby Dai Young in the wake of his team's Aviva Premiership defeat to Bath on Sunday.
Wade was in stunning form for Wasps prior to his injury setback having scored five tries in nine games this season, including a brilliant brace on his last outing against Gloucester on November 2.
The 22-year-old was named Player of the Year and Young Player of the Year at the end of last season after finishing as joint top scorer in the Aviva Premiership and crossing five times in as many games in the Amlin Challenge Cup.
He starred for England in Argentina in the summer and was subsequently called up for the British & Irish Lions in Australia, with his rise to prominence set to continue this month when he was due to start his first Test start at Twickenham when England took on Argentina.
Varndell was the man who shared the top scorer honour with Wade last term and he was hoping to start where he left off this season but has only managed one appearance to date, in the league opener with Harlequins at Twickenham on September 7.
While Wade could feature in the domestic clash with London Irish on Saturday, Varndell looks like missing that match and the home tie with Grenoble before being available for selection for Round 4 of the Amlin Challenge Cup in France.