However this game at Stadium Arcul de Triumf could prove pivotal for both team's ambitions of progressing.
Cammi Rugby Calvisano looked to be heading for victory over Brive thanks to tries from Ben De Jager and Michele Visentin but were forced to share the spoils after concede a late try and then missing a potential winning penalty in the final stages.
Similarly four kicks from the boot of fly-half Vali Calafeteanu saw Bucharest lead Newcastle Falcons 12-10 until the 74th minute when the strength of the English Premiership side's bench finally told to squeeze out Tom Catterick's late penalty.
Now both sides will be desperate to build on those performances but know they must take four points.
Wolves head coach Lynn Howells, who took Pontypridd to the Challenge Cup Final in 2002 and semi-finals in 2003, said: "This is a game that we have to target for a win. We beat them last season but they have obviously improved a lot after taking Brive all the way last week. We have three home games in a row and we want to get a couple of wins under our belt. But this pool is wide open.
Bucharest claimed their biggest score in Europe when they beat Calvisano 42-27 last season, running in a club record six tries.
- These two clubs met in the pool stage of last season's tournament with both sides securing home wins.
- Calvisano have just won once in their last nine games in the competition, against Bucharest last season (34-20) ; they are still looking for their first away win.
- Bucharest almost made it three consecutive home wins in this tournament before a last- gasp defeat at the hands of Newcastle in Round 1.
- Against Italian opposition, teams from Bucharest have won five of their six home games in the history of this tournament.