Wasps have lifted both the Heineken Cup and Challenge Cup but still managed to achieve a new milestone against Viadana with their biggest European victory.
Dai Young's side showed a ruthless streak with 14 tries in the 90-17 win over the Italian champions that included a hat-trick for William Helu on his debut.
Bayonne, who brought British & Irish Lion Mike Phillips off the bench, left it until the last minute against Grenoble to clinch a bonus point when Opeti Fonua crossed for their fourth try.
This is the fourth time in five years Wasps and Bayonne have been thrown together in the pool stage and while the Basque club managed just two wins from their 19 previous encounters with English opposition, one of those was a 19-11 success over Wasps in 2011.
Last year the teams drew 13-13 in the south of France and this tie looks set to be just as tight.
Grenoble have been the surprise package of the Top 14 but will not be happy at finding themselves towards the bottom of the pool.
But while they have never lost to Italian opposition, Viadana have a track record of getting the better of Grenoble's fellow countrymen and still managed to score two tries against Wasps last week thanks to Andrea Barbieri and Anthony Fenner.